Yesterday I returned from vacation, and went to sync my iPhone with iTunes on my desktop at home. I had about 250 application updates waiting for me, and between that and the volume of photos I took on vacation, the sync refused to finish. I thought about it for a minute, and then looked through page after page after page of apps on my phone. After transferring photos to my iMac via the Image Capture app (instead of iTunes), I decided to start fresh - and wiped the slate clean.
This is a problem us 16GB iPhone users simply don't have. I wish I could have this problem!