Hat tip to @mintshows on Twitter for this suggestion!
I really like Safari on my Mac. It's fast, clean, and easy to use. Sure, Chrome has some more features, but Safari just scratches the right itches for me and I want to use it all the time. There's just one problem: clicking links in Tweetbot just don't load. They hang there, seemingly waiting for something to happen, but nothing ever does.
Here's the fix!
Simply paste this into your Terminal and you'll fix the issue.
defaults write com.tapbots.TweetbotMac OpenURLsDirectly YES
Essentially what this does is have Tweetbot request the direct link that you clicked and not the t.co short link that Twitter would like you to use. It's a simple fix that won't help issues with Twitter links from other apps from working, but it's enough for me.